The nearest airport is SCU - Santiago De Cuba Antonio Maceo Intl, located 33.4 km south east of La Luisa.
Other airports nearby include BYM - Bayamo Carlos Manuel De Cespedes (69.7 km west), HOG - Holguin Frank Pais Intl (70.0 km north west), GAO - Guantanamo Mariana Grajales (87.1 km east), MZO - Manzanillo Sierra Maestra (116.6 km west),