The nearest airport is CMW - Camaguey Ignacio Agramonte Intl, located 50.9 km north west of San Manuel.
Other airports nearby include VTU - Las Tunas Hermanos Ameijeiras (74.3 km east), MZO - Manzanillo Sierra Maestra (98.1 km south east), BYM - Bayamo Carlos Manuel De Cespedes (126.3 km south east), HOG - Holguin Frank Pais Intl (140.9 km east),