The nearest airport is VTU - Las Tunas Hermanos Ameijeiras, located 50.0 km south east of Santa Lucía.
Other airports nearby include CMW - Camaguey Ignacio Agramonte Intl (73.1 km west), HOG - Holguin Frank Pais Intl (109.3 km south east), MZO - Manzanillo Sierra Maestra (122.7 km south), BYM - Bayamo Carlos Manuel De Cespedes (123.2 km south east),