The nearest airport is PVK - Preveza Aktio, located 32.2 km south of Despotikón.
Other airports nearby include IOA - Ioannina (56.1 km north), CFU - Kerkyra/corfu Ioannis Kapodistrias Intl (78.7 km north west), AGQ - Agrinion (89.4 km south east), EFL - Keffallinia Kefallinia (121.4 km south),