The nearest airport is HOG - Holguin Frank Pais Intl, located 19.0 km south west of Santa Lucía.
Other airports nearby include BYM - Bayamo Carlos Manuel De Cespedes (71.2 km south west), VTU - Las Tunas Hermanos Ameijeiras (82.6 km west), SCU - Santiago De Cuba Antonio Maceo Intl (104.4 km south), MZO - Manzanillo Sierra Maestra (116.6 km south west),