The nearest airport is VSA - Villahermosa C P A Carlos Rovirosa Intl, located 70.2 km west of Santa Cruz.
Other airports nearby include CME - Ciudad Del Carmen Intl (71.0 km north east), TGZ - Tuxtla Gutierrez Angel Albino Corzo (194.8 km south west), CPE - Campeche Ingeniero Alberto Acuna Ongay Intl (257.3 km north east),