The nearest airport is TXA - Tlaxcala, located 38.4 km south east of Santa Cruz.
Other airports nearby include PCA - Pachuca Ingeniero Juan Guillermo Villasana (50.1 km north west), PBC - Puebla Hermanos Serdan Intl (72.9 km south), MEX - Mexico City Licenciado Benito Juarez Intl (82.9 km south west), PAZ - Poza Rico Tajin (130.5 km north east),