The nearest airport is SLP - San Luis Potosi Ponciano Arriaga Intl, located 31.0 km south west of Zapotillo.
Other airports nearby include BJX - Del Bajio Guanajuato Intl (178.7 km south west), AGU - Aguascalientes Jesus Teran Intl (185.4 km south west), TSL - Tamuin (200.0 km east), QRO - Queretaro Intercontinental (208.0 km south),