The nearest airport is EOH - Medellin Olaya Herrera, located 46.6 km south of Mestizal.
Other airports nearby include MDE - Rio Negro Jose Maria Cordova (55.5 km south), OTU - Otu (103.9 km north east), UIB - Quibdo El Carano (157.6 km south west), MZL - Manizales La Nubia (178.7 km south),