The nearest airport is EOH - Medellin Olaya Herrera, located 45.2 km south of Palacio.
Other airports nearby include MDE - Rio Negro Jose Maria Cordova (59.4 km south east), OTU - Otu (121.1 km east), UIB - Quibdo El Carano (142.5 km south west), MZL - Manizales La Nubia (176.5 km south),