The nearest airport is TCN - Tehuacan, located 51.4 km north east of Mezquital.
Other airports nearby include PBC - Puebla Hermanos Serdan Intl (136.7 km north west), OAX - Oaxaca Xoxocotlan Intl (159.6 km south east), TXA - Tlaxcala (166.2 km north), CVJ - Cuernavaca General Mariano Matamoros (184.6 km north west),