The nearest airport is CPE - Campeche Ingeniero Alberto Acuna Ongay Intl, located 69.4 km south west of Santa Cruz.
Other airports nearby include MID - Merida Licenciado Manuel Crescencio Rejon Int (82.7 km north east), CME - Ciudad Del Carmen Intl (256.3 km south west), CTM - Chetumal Intl (273.7 km south east),