The nearest airport is LRD - Laredo Intl, located 10.7 km south east of Santa Cruz.
Other airports nearby include NLD - Nuevo Laredo Quetzalcoatl Intl (17.4 km south), PDS - Piedras Negras Intl (149.4 km north west), ALI - Alice Intl (151.1 km east), NQI - Kingsville Nas (172.2 km east),