The nearest airport is PDS - Piedras Negras Intl, located 39.7 km north east of Santa Cruz.
Other airports nearby include DLF - Del Rio Laughlin Afb (117.7 km north), NLD - Nuevo Laredo Quetzalcoatl Intl (146.2 km south east), LRD - Laredo Intl (147.9 km south east), LOV - Monclova Intl (167.2 km south west),