The nearest airport is TLC - Toluca Licenciado Adolfo Lopez Mateos Intl, located 44.7 km south of Santa Cruz.
Other airports nearby include MEX - Mexico City Licenciado Benito Juarez Intl (70.9 km south east), PCA - Pachuca Ingeniero Juan Guillermo Villasana (101.0 km north east), CVJ - Cuernavaca General Mariano Matamoros (107.9 km south east), QRO - Queretaro Intercontinental (112.1 km north west),