The nearest airport is CME - Ciudad Del Carmen Intl, located 64.1 km north of Santa Cruz.
Other airports nearby include VSA - Villahermosa C P A Carlos Rovirosa Intl (131.3 km west), CPE - Campeche Ingeniero Alberto Acuna Ongay Intl (220.4 km north east), TGZ - Tuxtla Gutierrez Angel Albino Corzo (230.1 km south west),