The nearest airport is HOG - Holguin Frank Pais Intl, located 37.4 km south of Cupeicillo.
Other airports nearby include VTU - Las Tunas Hermanos Ameijeiras (79.2 km west), BYM - Bayamo Carlos Manuel De Cespedes (90.3 km south west), SCU - Santiago De Cuba Antonio Maceo Intl (130.3 km south), MZO - Manzanillo Sierra Maestra (130.3 km south west),