The nearest airport is HOG - Holguin Frank Pais Intl, located 66.3 km west of Guayabo.
Other airports nearby include SCU - Santiago De Cuba Antonio Maceo Intl (74.8 km south), MOA - Moa Orestes Acosta (81.1 km east), GAO - Guantanamo Mariana Grajales (82.9 km south east), BYM - Bayamo Carlos Manuel De Cespedes (99.6 km west),