The nearest airport is HOG - Holguin Frank Pais Intl, located 26.8 km east of Guayabo.
Other airports nearby include VTU - Las Tunas Hermanos Ameijeiras (41.5 km west), BYM - Bayamo Carlos Manuel De Cespedes (52.2 km south), MZO - Manzanillo Sierra Maestra (84.4 km south west), SCU - Santiago De Cuba Antonio Maceo Intl (124.5 km south east),