The nearest airport is HOG - Holguin Frank Pais Intl, located 28.4 km east of Guayacán.
Other airports nearby include VTU - Las Tunas Hermanos Ameijeiras (40.0 km west), BYM - Bayamo Carlos Manuel De Cespedes (52.9 km south), MZO - Manzanillo Sierra Maestra (84.2 km south west), SCU - Santiago De Cuba Antonio Maceo Intl (126.0 km south east),