The nearest airport is HOG - Holguin Frank Pais Intl, located 29.1 km west of Margarita.
Other airports nearby include BYM - Bayamo Carlos Manuel De Cespedes (78.6 km south west), VTU - Las Tunas Hermanos Ameijeiras (93.7 km west), SCU - Santiago De Cuba Antonio Maceo Intl (100.5 km south), MOA - Moa Orestes Acosta (119.2 km east),