The nearest airport is SCU - Santiago De Cuba Antonio Maceo Intl, located 24.2 km south of San Luis.
Other airports nearby include GAO - Guantanamo Mariana Grajales (73.3 km east), HOG - Holguin Frank Pais Intl (82.0 km north west), BYM - Bayamo Carlos Manuel De Cespedes (83.8 km west), MOA - Moa Orestes Acosta (109.8 km north east),