The nearest airport is SCU - Santiago De Cuba Antonio Maceo Intl, located 44.2 km south of Santa Fe.
Other airports nearby include HOG - Holguin Frank Pais Intl (64.6 km north west), BYM - Bayamo Carlos Manuel De Cespedes (77.1 km west), GAO - Guantanamo Mariana Grajales (81.9 km east), MOA - Moa Orestes Acosta (105.2 km east),