The nearest airport is GAO - Guantanamo Mariana Grajales, located 38.1 km east of Santa Isabel.
Other airports nearby include SCU - Santiago De Cuba Antonio Maceo Intl (38.9 km south west), MOA - Moa Orestes Acosta (83.4 km north east), BCA - Baracoa Playa Gustavo Rizo (108.2 km east), HOG - Holguin Frank Pais Intl (109.0 km north west),