The nearest airport is CMW - Camaguey Ignacio Agramonte Intl, located 20.1 km north east of Santa Isabel.
Other airports nearby include VTU - Las Tunas Hermanos Ameijeiras (109.8 km east), AVI - Ciego De Avila Maximo Gomez (121.0 km north west), MZO - Manzanillo Sierra Maestra (140.6 km south east), BYM - Bayamo Carlos Manuel De Cespedes (168.5 km south east),