The nearest airport is AVI - Ciego De Avila Maximo Gomez, located 50.6 km west of Santa Isabel.
Other airports nearby include CMW - Camaguey Ignacio Agramonte Intl (82.5 km south east), SNU - Santa Clara Abel Santamaria (176.9 km west), VTU - Las Tunas Hermanos Ameijeiras (182.7 km south east), MZO - Manzanillo Sierra Maestra (230.5 km south east),