The nearest airport is VRA - Varadero Juan Gualberto Gomez Intl, located 61.1 km north west of Santa Isabel.
Other airports nearby include CFG - Cienfuegos Jaime Gonzalez (87.8 km south east), CYO - Cayo Vilo Acuna Intl (111.2 km south), SNU - Santa Clara Abel Santamaria (124.3 km east), HAV - Havana Jose Marti Intl (138.1 km west),