The nearest airport is SCU - Santiago De Cuba Antonio Maceo Intl, located 17.4 km west of Santa Isabel.
Other airports nearby include GAO - Guantanamo Mariana Grajales (55.4 km east), MOA - Moa Orestes Acosta (109.8 km north east), BYM - Bayamo Carlos Manuel De Cespedes (110.7 km north west), HOG - Holguin Frank Pais Intl (113.8 km north west),