The nearest airport is SCU - Santiago De Cuba Antonio Maceo Intl, located 30.5 km south east of Vega Grande.
Other airports nearby include BYM - Bayamo Carlos Manuel De Cespedes (68.8 km west), HOG - Holguin Frank Pais Intl (72.9 km north west), GAO - Guantanamo Mariana Grajales (88.5 km east), MZO - Manzanillo Sierra Maestra (114.6 km west),