The nearest airport is CME - Ciudad Del Carmen Intl, located 89.3 km north of Santa Cruz.
Other airports nearby include VSA - Villahermosa C P A Carlos Rovirosa Intl (89.5 km west), TGZ - Tuxtla Gutierrez Angel Albino Corzo (182.1 km south west), CPE - Campeche Ingeniero Alberto Acuna Ongay Intl (266.5 km north east),