The nearest airport is VSA - Villahermosa C P A Carlos Rovirosa Intl, located 87.8 km west of Santa Cruz.
Other airports nearby include CME - Ciudad Del Carmen Intl (89.7 km north), TGZ - Tuxtla Gutierrez Angel Albino Corzo (181.0 km south west), CPE - Campeche Ingeniero Alberto Acuna Ongay Intl (267.5 km north east),