The nearest airport is AVI - Ciego De Avila Maximo Gomez, located 37.3 km south east of Mayajigua.
Other airports nearby include SNU - Santa Clara Abel Santamaria (94.3 km west), CFG - Cienfuegos Jaime Gonzalez (139.1 km west), CMW - Camaguey Ignacio Agramonte Intl (155.6 km south east), MZO - Manzanillo Sierra Maestra (298.3 km south east),