The nearest airport is TCN - Tehuacan, located 99.3 km west of Guadalupe.
Other airports nearby include VER - Vera Cruz General Heriberto Jara Intl (105.1 km north), OAX - Oaxaca Xoxocotlan Intl (140.1 km south), MTT - Minatitlan (205.5 km east), PBC - Puebla Hermanos Serdan Intl (219.9 km north west),