The nearest airport is MAM - Matamoros General Servando Canales Intl, located 25.5 km north of Guadalupe.
Other airports nearby include BRO - Brownsville South Padre Island Intl (43.2 km north east), HRL - Harlingen Valley Intl (75.4 km north), REX - Reynosa General Lucio Blanco Intl (81.0 km north west), MFE - Mcallen Mc Allen Miller Intl (94.4 km north west),