The nearest airport is AVI - Ciego De Avila Maximo Gomez, located 19.1 km south east of Guadalupe.
Other airports nearby include SNU - Santa Clara Abel Santamaria (110.5 km north west), CMW - Camaguey Ignacio Agramonte Intl (137.2 km south east), CFG - Cienfuegos Jaime Gonzalez (150.2 km west), MZO - Manzanillo Sierra Maestra (278.9 km south east),