The nearest airport is AVI - Ciego De Avila Maximo Gomez, located 22.2 km north east of Guayacanes.
Other airports nearby include CMW - Camaguey Ignacio Agramonte Intl (123.7 km south east), SNU - Santa Clara Abel Santamaria (124.1 km north west), CFG - Cienfuegos Jaime Gonzalez (155.5 km west), MZO - Manzanillo Sierra Maestra (260.5 km south east),