The nearest airport is HOG - Holguin Frank Pais Intl, located 26.6 km south west of La Demajagua.
Other airports nearby include VTU - Las Tunas Hermanos Ameijeiras (76.5 km west), BYM - Bayamo Carlos Manuel De Cespedes (80.0 km south west), SCU - Santiago De Cuba Antonio Maceo Intl (120.2 km south), MZO - Manzanillo Sierra Maestra (121.7 km south west),