The nearest airport is VTU - Las Tunas Hermanos Ameijeiras, located 41.9 km east of Palo Seco.
Other airports nearby include CMW - Camaguey Ignacio Agramonte Intl (64.6 km north west), MZO - Manzanillo Sierra Maestra (95.1 km south), BYM - Bayamo Carlos Manuel De Cespedes (107.8 km south east), HOG - Holguin Frank Pais Intl (110.3 km east),