The nearest airport is HOG - Holguin Frank Pais Intl, located 39.9 km south of Pupos.
Other airports nearby include VTU - Las Tunas Hermanos Ameijeiras (63.2 km west), BYM - Bayamo Carlos Manuel De Cespedes (87.5 km south), MZO - Manzanillo Sierra Maestra (122.1 km south west), SCU - Santiago De Cuba Antonio Maceo Intl (140.7 km south),