The nearest airport is CMW - Camaguey Ignacio Agramonte Intl, located 44.5 km west of San Manuel.
Other airports nearby include VTU - Las Tunas Hermanos Ameijeiras (63.2 km south east), MZO - Manzanillo Sierra Maestra (119.4 km south), HOG - Holguin Frank Pais Intl (130.2 km south east), BYM - Bayamo Carlos Manuel De Cespedes (132.4 km south east),