The nearest airport is GAO - Guantanamo Mariana Grajales, located 26.8 km south east of San Manuel.
Other airports nearby include SCU - Santiago De Cuba Antonio Maceo Intl (55.0 km south west), MOA - Moa Orestes Acosta (68.1 km north east), BCA - Baracoa Playa Gustavo Rizo (92.5 km east), HOG - Holguin Frank Pais Intl (116.6 km north west),