The nearest airport is SCU - Santiago De Cuba Antonio Maceo Intl, located 34.0 km south of Santa Isabel.
Other airports nearby include HOG - Holguin Frank Pais Intl (73.5 km north west), GAO - Guantanamo Mariana Grajales (76.7 km east), BYM - Bayamo Carlos Manuel De Cespedes (80.2 km west), MOA - Moa Orestes Acosta (106.9 km north east),