The nearest airport is VTU - Las Tunas Hermanos Ameijeiras, located 48.4 km east of Santa Lucía.
Other airports nearby include CMW - Camaguey Ignacio Agramonte Intl (64.5 km north west), MZO - Manzanillo Sierra Maestra (86.9 km south), BYM - Bayamo Carlos Manuel De Cespedes (106.3 km south east), HOG - Holguin Frank Pais Intl (115.7 km east),