The nearest airport is SCU - Santiago De Cuba Antonio Maceo Intl, located 35.4 km south of San Nicolás.
Other airports nearby include HOG - Holguin Frank Pais Intl (70.5 km north west), BYM - Bayamo Carlos Manuel De Cespedes (76.4 km west), GAO - Guantanamo Mariana Grajales (80.6 km east), MOA - Moa Orestes Acosta (110.0 km east),