The nearest airport is PDS - Piedras Negras Intl, located 53.3 km north of Guadalupe.
Other airports nearby include NLD - Nuevo Laredo Quetzalcoatl Intl (128.1 km south east), LRD - Laredo Intl (130.7 km south east), DLF - Del Rio Laughlin Afb (135.2 km north), LOV - Monclova Intl (157.8 km south west),