The nearest airport is PDS - Piedras Negras Intl, located 53.5 km north of Guadalupe.
Other airports nearby include NLD - Nuevo Laredo Quetzalcoatl Intl (129.4 km south east), LRD - Laredo Intl (132.1 km south east), DLF - Del Rio Laughlin Afb (135.0 km north), LOV - Monclova Intl (156.9 km south west),