The nearest airport is CMW - Camaguey Ignacio Agramonte Intl, located 59.7 km east of San Nicolás.
Other airports nearby include AVI - Ciego De Avila Maximo Gomez (72.4 km north west), VTU - Las Tunas Hermanos Ameijeiras (163.2 km east), MZO - Manzanillo Sierra Maestra (190.7 km south east), SNU - Santa Clara Abel Santamaria (193.7 km north west),